| Darsteller | Rolle |
|---|---|
| Jerry O'Connell | Commander Jack Ransom (19) Jack Ransom (10) |
| Gillian Vigman | Doctor T’Ana (10) T’Ana (10) Dr. T'Ana (9) |
| Dawnn Lewis | Captain Carol Freeman (19) Carol Freeman (10) |
| Fred Tatasciore | Shaxs (19) Lieutenant Shaxs (10) |
| Jack Quaid | Ensign Brad Boimler (19) Brad Boimler (10) |
| Eugene Cordero | Ensign Sam Rutherford (10) Sam Rutherford (10) Ensign Samanthan Rutherford (9) |
| Tawny Newsome | Ensign Beckett Mariner (19) Beckett Mariner (10) |
| Noel Wells | Ensign D'Vana Tendi (19) D'Vana Tendi (10) |
| Paul Scheer | Andarithio 'Andy' Billups (6) Andy Billups (6) Andy Billups / Addix's Species Bouncer Andy Billups / Drookmani crewmember 1 |
| Gabrielle Ruiz | T'Lyn (5) T'Lyn / Castro (5) T'Lyn / Ariolo Federation Scientist (2) Castro / T'Lyn T'Lyn / Radiara |
| Paul F. Tompkins | Migleemo (4) Gabers Migleemo / Zurkel (2) Vrek (2) |
| Carl Tart | Kayshon (3) Kayshon / Clicket infiltrator 2 (2) Kayshon / Relga's Bridge Officer Kayshon / Sexagus |
| Nolan North | B'Rt Tendi (3) Cadet Lars Lundy Livik |
| Jessica McKenna | Barnes (6) |
| Kari Wahlgren | B'eth (2) Cosmia / Key'lor Key'lor L'Kar |
| Eric Bauza | Coqqor Dar / Jeef Gem Jeef Snell |
| Phil LaMarr | Alonzo Freeman (3) Dirk / Wadi Recreation 1 |
| Ariel Winter | D'Erika Tendi (4) |
| Jon Brent Curry | Ma'ah (4) |
| Wendie Malick | Cathiw |
| Jolene Blalock | T'Pol |
| Dave Foley | Parth |
| Stephen Root | Gene Jakobowski |
| Wil Wheaton | Wesley Crusher |
| Alexander Siddig | Dr. Julian Bashir |
| Liam McIntyre | Harrison Horseberry |
| Lauren Lapkus | Jennifer Sh'reyan |
| Charlotte Nicdao | Meredith (3) |
| Oscar Montoya | Mackler (2) Vexilon |
| Sam Witwer | Legnog Malor |
| Vanessa Marshall | D'Bora Shona Tendi |
| Debra Wilson | Sabor Z'oto |
| Robert Duncan McNeill | Nick Locarno (2) |
| James Sie | Doctor Chaotica / G'reck Westlake / Cardassian soldier |
| Saba Homayoon | Ensign Olly Olly |
| Artemis Pebdani | Karavitus (2) |
| Nicole Byer | Kassia Nox (2) |
| Andy Richter | Beljo Tweekle |
| Chase Masterson | Leeta |
| Andrew Robinson | Elim Garak |
| Jess Harnell | K'orin / Warrior Pit Bartender |
| Jeffrey Combs | AGIMUS |
| Alfre Woodard | Lilly Sloane |
| Brent Spiner | Data |
| Rachel Dratch | Dolorex |
| Toby Huss | Milius |
| Kether Donohue | Peanut Hamper |
| Max Grodénchik | Rom |
| Jack McBrayer | Badgey / Goodgey / Logic-y |
| Colton Dunn | Bargh |
| Garrett Wang | Harry Kim |
| Asif Ali | Asif / Grafflax |
| Roxana Ortega | Relga |
| Jon Barinholtz | Gorm |
| Gideon Adlon | Haubold |
| Shannon Fill | Sito Jaxa |
| Marcus Henderson | Krog / Jet Manhaver |
| Ben Rodgers | Steve Stevens |
| Kimiko Glenn | G |
| Dulce Sloan | Enaj / Klowahkan greeter 1 |
| Chris Perfetti | Gary |
| Mary Holland | Moxy |
| Zach Cherry | Amadou |
| Mary Chieffo | K'Elarra |
| Janelle James | Katrot |