| Darsteller | Rolle |
|---|---|
| Patton Oswalt | M.O.D.O.K. (10) |
| Aimee Garcia | Jodie Tarleton (9) |
| Ben Schwartz | Lou Tarleton (9) |
| Jonathan C. Daly | Super-Adaptoid (8) |
| Melissa Fumero | Melissa Tarleton (8) |
| Wendi McLendon-Covey | Monica Rappaccini (6) |
| Sam Richardson | Gary (3) Gary Garoldson (3) |
| Beck Bennett | Austin Van Der Sleet (4) Austin Van Der Sleet / José Austin Van Der Sleet / Kobolt |
| Jon Hamm | Tony Stark / Iron Man (4) |
| Nathan Fillion | Simon Williams / Wonder Man (2) |
| Alan Tudyk | Arcade (2) |
| Bill Hader | David Alan Angar / Angar the Screamer / Future A.I.M. Agent Samuel Sterns / The Leader / David Alan Angar / Angar the Scream |
| Brian Posehn | General Dagger |
| Whoopi Goldberg | Marian Pouncy / Poundcakes |
| Zara Mizrahi | Carmilla Rappaccini (3) |
| Kevin Michael Richardson | David Cannon / Whirlwind Nathaniel Essex / Mr. Sinister / David Cannon / Whirlwind / Jero |
| Meredith Salenger | Brandi Whitney Frost / Madame Masque / Club Supervisor |
| John Di Maggio | A.I.M. agent Rodney |
| Lennon Parham | Doris / Mrs. Horgan (2) |
| Dustin Ybarra | Antonio Rodriguez / Armadillo (2) |
| Chris Parnell | Alvin Healy / Tenpin |
| Eddie Pepitone | Bruno Horgan / Melter |
| Trevor Devall | Balder the Brave |
| Jonathan Van Ness | Jon-Jon |