| Darsteller | Rolle |
|---|---|
| Ignazio Oliva | Valente (10) |
| Jude Law | Lenny Belardo (10) |
| Diane Keaton | Sister Mary (10) |
| Silvio Orlando | Cardinal Voiello (10) |
| Javier Camara | Cardinal Gutierrez (10) |
| Scott Shepherd | Cardinal Dussolier (10) |
| Cecile De France | Sofia (10) |
| Ludivine Sagnier | Esther (10) |
| Toni Bertorelli | Cardinal Caltanissetta (10) |
| James Cromwell | Cardinal Michael Spencer (10) |
| Marcello Romolo | Don Tommaso (9) Don Tommaso Viglietti (2) |
| Armando Pizzuti | Priest Triregno (7) |
| Olivia Macklin | Madre (7) |
| Frank Gingerich | Young Lenny (7) |
| Allison Case | Young Sister Mary (7) |
| Daniel Vivian | Domen (7) |
| Sara Lazzaro | Cloistered Nun (6) |
| Vladimir Bibic | Ozolins (6) |
| Ramón García | Aguirre (6) |
| Jim Adhi Limas | |
| Edoardo Bussi | Girolamo (6) |
| Gianluca Guidi | Father Amatucci (6) |
| Jack McQuaid | Young Dussolier (5) |
| Collin Smith | Padre (5) |
| Nadee Kammellaweera | Sister Suree (5) |
| Maurizio Lombardi | Cardinal Mario Assente (5) |
| Sebastian Roche | Cardinal Michel Marivaux (5) |
| Biagio Forestieri | Peter (4) |
| Jacob Desvarieux | African Cardinal (4) |
| Alessia Giulia Trujillo Alva | Juana Fernandez (3) |
| Rayna Tharani | Maribeth (3) |
| Giancarlo Fares | Girolamo's Caregiver (3) |
| Tony Plana | Carlos García (3) |
| Delaina Mitchell | Lenny's Ex-Girlfriend (2) |
| Janet Frances Baines | Sister Bice (2) |
| Nicoletta Cefaly | Sister Spencer N.1 (2) |
| Monica Cetti | Countess Meraviglia (2) |
| Alessandra Fallucchi | Sister Spencer N.2 (2) |
| Carolina Carlsson | Prime Minister of Greenland (2) |
| Camilla Diana | Saint Mary (2) |
| Stefano Accorsi | Italian Prime Minister (2) |
| Madalina Bellariu Ion | |
| Franco Pinelli | Tonino Pettola (2) |
| Ann Carr | |
| Brian Keane | Custodian (2) |
| Jan Hoag | Rose (2) |
| Alex Esola | Freddy Blakestone (2) |
| Luke Grakal | Ex-Girlfriend's Son (2) |
| Giuseppe Sanfelice | Reporter on the Plane Press Conference Reporter |
| Guy Boyd | Archbishop Kurtwell (2) |
| Troy Ruptash | David Tanistone (2) |
| Kevin Jackson | Pete Washington (2) |
| Francesca Cutolo | Reporter on the Plane Press Conference Reporter |
| Robert Brodie Booth | Reporter on the Plane Press Conference Reporter |
| Andre Gregory | Elmore Coen (2) |
| Lino Musella | Tonino's Disciple |
| Fayelyn Bilodeau | TV Journalist USA |
| Steven Clancy | |
| Euridice Axén | TV Moderator |
| Emmanuel Pasqualini | Greenland Prime Minister's Assistant |
| Diego Maradona | |
| Pablo Ramos | Church Goer |
| Mattia Sbragia | Bishop of Belluno |
| Alexia Murray | Press Conference Reporter |
| Sean Patrick Campbell | |
| Donatella Bartoli | Nun |
| Riku Takeda | Tourist |
| Matteo Lai | Tour Guide |
| Giovanni Agrò | |
| Patrick Mitchell | Young Lenny |
| Andrew Plinio | Billy |
| Andrew R. Wolf | |
| Ashley Watkins | Beautiful Figure Skater |
| Pierre van Heerden | Reporter on the Plane |
| Jacelyn Parry | Cloister Nun |
| Alessio Montagnani | Ludovico Meraviglia |
| Fabrizio Jovine | Mr. Meraviglia |
| Milvia Marigliano | Sister Antonia |
| Alessio Praticò | Appuntato scelto |
| Davide Cincis | Poor Order Priest |
| Gil Perez-Abraham | Cardinal Dussolier's Lover |
| Adolph de Beer | |
| Jeanne Neilson | Reporter on the Plane |
| Todd Grinnell | Deacon Kurtwell |
| Duccio Camerini | Seminary Priest |
| Chris April | African Priest |
| Marcos Franz | Ángelo Sanchez |
| Dino Conti | |
| Massimiliano Gallo | Captain Becchi |
| Lea Gramsdorff | |
| Lorenzo Profita | Pilot |
| Robert Dawson | Imposter |
| Nicolas Coster | American Journalist |