| Darsteller | Rolle |
|---|---|
| Sarah Paulson | Aileen Wuornos (8) |
| Charlie Hunnam | Andrew Borden (8) |
| Vicky Krieps | Bridget Sullivan (8) |
| Jessica Barden | Nance O'Neil (8) |
| Billie Lourd | Emma Borden (8) |
| Rebecca Hall | Abby Borden (8) |
| Ella Beatty | Lizzie Borden (8) |
| Stogi Amir Kenyatta | 8-Year-Old Emma (2) Angela Gardener Monsignor Shelby |
| Oliver Spenceman | Stephen (6) |
| Joey Polari | John Morse (5) |
| Samantha Cormier | Sarah Anthony Borden (3) |
| Fred Maske | Postmaster (2) |
| Michael Tighe | Pharmacist (2) |
| Herbert Russell | Coroner (2) |
| Linda Reiter | Bertha Manchester (2) |
| Chad Coe | Deputy Francis Wixon (2) |
| Joseph Schwartz | Officer George Allen (2) |
| Aimee McGuire | Margaret (2) |
| Madylin Sweeten | Trixie |
| David St. James | Doctor |
| Jim Cody Williams | Fishmonger |
| Stewart Skelton | Minister |
| Tom Virtue | Doctor |
| Alan Heitz | Detective John Devine |
| Lauri Hendler | Mrs. Enid Wheatley |
| Troy Blendell | Coroner |
| Doug Cox | Juror #4 |
| Jay Christianson | Jury Foreman |
| Robbie Kaller | Steven Glazer |
| John Ales | Hosea Knowlton |
| Ezra Buzzington | Detective Michael Mullaly |
| Ari Graynor | Michelle Gillen |
| Joshua Close | Officer Patrick Doherty |
| Therese McLaughlin | Widow |
| Gabrielle Sanalitro | Lead Juror |
| A.J. Tannen | Judge Thomas Saway |
| Kristy Munden | Constance Meade |
| Joanna Leeds | Tricia Jenkins |
| Steven Lee Allen | Juror #6 |
| Trilby Glover | Thandie Wilcox |
| Aaron Hendry | Oberon |
| Michael O'Connell | Defense Attorney |
| Brian Tichnell | Playgoer |
| Hugo Armstrong | Harlan |
| Jeanine Anderson | Neighbor |
| Tom Fitzpatrick | Judge |
| Abby Wathen | Dawn Botkins |
| Christopher O'Shea | Heath Westcott |
| Dorian Martin | Reporter |
| Gabriel Sousa | Tiago |
| Michael X. Sommers | Juror #8 |
| Luca Pusceddu | Partygoer |
| Samuel Dunning | Policeman |
| Jordan Hendricks | Assistant District Attorney |
| Sandra Kate Burck | Daughter |
| Zachary Mooren | Atelier |
| Matthew Siegan | Reporter |
| Brian Knoebel | Son |
| Lidia Vitale | Servant |
| Jack Lancaster | Brother Borden |
| Jim O'Brien | Judge Uriel Blount |
| Michael McCusker | Bard Wainwright |
| Elizabeth Scopel | Callie |
| Jacopo Olmo Antinori | Western Union Man |
| Greg Barnett | AP William Moody |
| Flavia Leone | Middle Daughter |
| Cindy Michelle | Neighbor |
| Anthony J. Tremé | Muckraker |
| Bernadette Guckin | Carolyn |