| Darsteller | Rolle |
|---|---|
| Josh Hartnett | Ethan Chandler (27) |
| Harry Treadaway | Dr. Victor Frankenstein (27) |
| Billie Piper | Brona Croft (9) Lily (18) |
| Rory Kinnear | The Creature (8) John Clare (19) |
| Eva Green | Vanessa Ives (27) |
| Timothy Dalton | Sir Malcolm Murray (27) |
| Reeve Carney | Dorian Gray (27) |
| Danny Sapani | Sembene (18) |
| Simon Russell Beale | Ferdinand Lyle (14) |
| Sarah Greene | Hecate Poole (13) |
| Douglas Hodge | Bartholomew Rusk (13) |
| Helen McCrory | Madame Kali (12) |
| Jack Hickey | Junior Inspector (11) |
| Olivia Llewellyn | Mina Harker (10) |
| Patti Lupone | Joan Clayton Dr. Seward (9) |
| Olivia Chenery | Witch #2 (9) |
| Nicole O'Neill | Witch #1 (9) |
| Wes Studi | Kaetenay (9) |
| Shazad Latif | Dr. Henry Jekyll (8) |
| Noni Stapleton | Gladys Murray (7) |
| Christian Camargo | Dr. Alexander Sweet (7) |
| Casper Allpress | Jack (7) |
| Samuel Barnett | Renfield (7) |
| Stephen Lord | Warren Roper (6) |
| Jessica Barden | Justine (6) |
| Tamsin Topolski | Lavinia Putney (5) |
| Ruth Gemmell | Octavia Putney (5) |
| Alex Price | Proteus (5) |
| Graham Butler | Peter Murray Peter (5) |
| David Haig | Oscar Putney (5) |
| Jonny Beauchamp | Angelique (5) |
| Pandora Colin | Marjorie (5) |
| Hannah Tointon | Maud Gunneson (4) |
| David Walsh | Poor Boy (4) |
| Robert Nairne | Vampire (4) |
| Gavin Fowler | Simon (4) |
| Perdita Weeks | Catriona Hartdegen (4) |
| Sean Gilder | Marshall Franklin Ostow (4) |
| Sebastian Croft | Boy Familiar (4) |
| Brian Cox | Jared Talbot (2) |
| Alun Armstrong | Vincent Brand (3) |
| Olly Alexander | Fenton (3) |
| Charlene Gleeson | Lily's Whore Whore #1 (2) |
| Steve Wilson | Attendant - Bedlam (3) |
| Jamie Ballard | Balfour (3) |
| Jack Greenlees | Lead Familiar (3) |
| Joe McAvera | Photographer (2) |
| David Warner | Professor Abraham Van Helsing (2) |
| Peter Robbie | Gentleman (2) |
| Martin Phillips | Stage Manager (2) |
| Lorcan Cranitch | Inspector Granworthy (2) |
| Owen Roe | Colonel Brewster Minister |
| Denis Conway | Middle Aged Man (2) |
| Ronan Vibert | Sir Geoffrey Hawkes (2) |
| Mark Quigley | Nobleman (2) |
| Charlotte Beckett | Beautiful Witch (2) |
| Aideen Wylde | Mother (2) |
| Dave Curry | Father (2) |
| Kieron Duffy | Boy Familiar #2 (2) |
| Mei Bignall | Whore #2 (2) |
| Brendan Gibson | Rance (2) |
| Calum MacPherson | Proprietor (2) |
| Paddy Rocks | |
| Jonathan Delaney Tynan | Colleague of Dr. Sweet (2) |
| Cokey Falkow | Scarman (2) |
| Henry Goodman | Priest |
| Oliver Cotton | Father Matthews |
| Richard Riddell | Nathaniel Morris |
| Peter Miles | Hospital Porter |
| Diane Jennings | Nurse Ruth |
| Joseph Millson | Captain Branson |
| Michael James Ford | Gordon Ives |
| Xavier Atkins | Young Peter |
| Fern Deacon | Young Mina |
| Lili Davies | Young Vanessa |
| Frank McCusker | Dr. Christopher Banning |
| Anna Chancellor | Claire Ives |
| Sandra Huzuneanu | The Beautiful Woman |
| Melissa Lawlor | Dorian's Partygoer |
| Bobby Aherne | Theatre Heckler / Rat-baiting Referee |
| Frank Prendergast | Other Gentleman |
| Stephen Bradley | Gentleman |
| George Hanover | Nanny |
| Hayley Canham | Girl Outside Church |
| Melissa Maria Carton | Screaming Woman |
| Nathan O'Toole | Ernest |
| Lucas Farren | William |
| Anthony Brophy | Alphonse |
| Gus Barry | Young Victor |
| Mary Stockley | Caroline Frankenstein |
| Leticia Dolera | Lady at the Séance |
| Rick Burn | Sailor |
| Paul Ward | Telegraph Clerk |
| Michael O'Flaherty | Police Sergeant |
| Jack Walsh | Barman |
| Amy De Bhrún | Prostitute |
| Graeme Redmond | Nobleman |
| Darragh O'Connor | Audience Member |
| Olivia Fahy | Cowgirl |
| Gary Fox | Felix |
| Dylan McDonough | Constable |
| Alvaro Lucchesi | Police Photographer |
| Helen Norton | Woman #2 |
| Mary Murray | Woman #1 |
| Pat McGrath | Mortuary Boss |
| Fady Elsayed | Lead Familiar |
| Alison McGirr | Beautiful Young Woman |
| Karla Lyons | 7 Year Old Girl |
| Aoife Byrne | Mother |
| Pagan McGrath | Gladys' Maid |
| Matthew O'Brien | Man at Opera #2 |
| Anthony Delaney | Man at Opera #1 |
| Rachael Dowling | Dress Shop Owner |
| Gail Fitzpatrick | Tavern Woman |
| Jer O'Leary | Jack |
| Carla Langley | Pregnant Teenage Girl |
| Frank Smith | Curator |
| Barbara Brennan | Mrs. Bazarov |
| Rosemary Henderson | |
| Ross Mac Mahon | Bored Policeman |
| David Ryan | Doctor |
| Ben Harte | Chimney Sweep Apprentice |
| Morgan Jones | Broker |
| Aonghus Og McAnally | Docker |
| Tamsin Greene Barker | Whore |
| Sonya O'Donoghue | Grieving Mother |
| Bryan Baker | Museum Employee |
| Jack Hamilton | Fencer #1 |
| Adam Behan | Jared's Man |
| Jonathan Chan-Pensley | Mahjong Parlour Owner |
| Matt McClure | Rancher |
| Jaimie Carswell | Train Man #2 |
| Liam Hourican | Train Man #1 |
| Olga Wehrly | Suffragette Leader |
| Ian Patterson | Salesman |
| Darren Lyons | Red Coat Officer |
| Mirsad Ibisevic | Waiter |
| Adam William Cahill | Red Coat Soldier |
| Tantoo Cardinal | Old Native American Woman |
| Richard Doubleday | Magic Lantern Proprietor |
| Paul McCloskey | |
| Aine Hayden | Woman |
| Jack Olohan | Sailor #2 |
| Bradley Hall | Sailor #1 |
| Andrew Bridgmont | Ship Doctor |
| Elif Knight | Beggar Woman |
| Patrick Joseph Byrnes | Barman - Train |
| Julian Black Antelope | Mr. Kidd |
| Chris McHallem | Gun Shop Proprietor |
| Amber Fernée | Clare Chandler |
| Noah Jupe | Charles Chandler |
| Sophie Meade | Teenage Singing Girl |
| Fabien Oman | Familiar #1 |
| Henri Välikangas | Familiar |