| Darsteller | Rolle |
|---|---|
| Naomi Watts | Jackie Kennedy Onassis (9) |
| Grace Gummer | Caroline Kennedy (9) |
| Alessandro Nivola | Calvin Klein (9) |
| Leila George | Kelly Klein (9) |
| Sydney Lemmon | Lauren Bessette (9) |
| Sarah Pidgeon | Carolyn Bessette (9) |
| Paul Kelly | John F. Kennedy Jr. (9) |
| Kevyn Aucoin | Schlossberg Child (2) Billy Family Friend #2 MIchael Kennedy Paparazzi #3 Parker Petty Officer |
| Ben Shenkman | Edwin 'Ed' Schlossberg (7) |
| Michael Nathanson | Michael Berman (6) |
| Erich Bergen | Anthony Radziwill (6) |
| Tonatiuh Elizarraraz | Narciso Rodriguez (5) |
| Omari K. Chancellor | Gordon Henderson (5) |
| Aida Leventaki | Jane (4) |
| Noah Fearnley | Michael Bergin (4) |
| Constance Zimmer | Ann Marie Messina (3) |
| Donal Logue | Senator Edward 'Ted' Kennedy (3) |
| Adam Grupper | Maurice (3) |
| Jessica Harper | Ethel Skakel Kennedy (3) |
| Aaron Dean Eisenberg | Colin (3) |
| Richard Hollis | Eugie (3) |
| Grey Henson | Tommy (3) |
| Dree Hemingway | Daryl Hannah (3) |
| Freja Zeuthen | Jules (3) |
| Sarah Voigt | Vicki Kennedy (3) |
| Steven Cambria | Father Charles O'Byrne (2) |
| Nayab Hussain | Dr. Moore (2) |
| Sophie von Haselberg | Jill Kargman (2) |
| Sebastian White | Richard Freeman (2) |
| Vincent Minutella | Doorman (2) |
| Matthew Goodrich | Dave Kennedy (2) |
| Francois Chau | Newscaster |
| Talia Balsam | Dr. Colleen |
| Angela Reed | Nancy |
| Joseph Latimore | News Vendor |
| Charlene Amoia | Lawyer #2 |
| Bob Pescovitz | Henry Lehman |
| Jennifer Dorr White | Pearl Clutcher #2 |
| Jane Fergus | News Anchor #2 |
| Allen Fawcett | Monsignor Bardes |
| Mahadeo Shivraj | Waiter |
| Patrick Oliver Jones | Reporter #1 |
| Alan Wong | Director |
| Anthony Bradford | Whitney Reporter #1 |
| Nadia Quinn | Margaret |
| Tim Eliot | Joe Kennedy |
| Cary Donaldson | Troy |
| Brigid Brady | Pearl Clutcher #1 |
| Sasha Hutchings | Julia |
| Bryce Gangel | Katie |
| Sam Seferian | Reporter #3 |
| Vince Eisenson | Reporter #1 |
| Danny Vaccaro | Publishing Executive #2 |
| Jonathan Fielding | Paul Begala |
| Megan Channell | Annette Bening |
| Josh Tobin | Reporter #2 |
| Kerry Flanagan | Nurse |
| Chris Kimball | Alan |
| Emily Behny | Event Coordinator |
| Victor Albaum | Aggressive Fan |
| Richard Neil | Todd |
| Ava Eisenson | Allison |
| Nicholas Delany | Bobby Shriver |
| Kaylin Lee Clinton | Serena |
| Drew Hinckley | Executive |
| Tom Ashton | Lawyer #1 |
| Stephen Cerf | Ralph Lauren Executive #2 |
| Haskell King | Publishing Executive #1 |
| Lia Lando | Newscaster |
| Viveca Chow | Grace |
| Clio Contogenis | Shandra |
| Ayla Eloy | Sonia |
| James M. Reilly | Whitney Reporter #2 |
| Colleen Davie Janes | Police Officer #2 |
| David Gazzo | Paparazzi #1 |
| Ruth Kavanagh | Maid |
| Krystian Bester | Bouncer |